New Orleans Saints running back Mark Ingram running with the football

New Orleans Saints running back Mark Ingram in action during an NFL football game against the Philadelphia Eagles Sunday, Nov. 21, 2021, in Philadelphia. (AP Photo/Matt Rourke)

  • The Buffalo Bills are 6.5-point road favorites over the New Orleans Saints the NFL’s Week 12 edition of TNF on Thursday, November 25
  • 79% of the public money is on the Bills to cover the spread
  • See all the betting trends and latest injury report for Bills vs Saints below

Both the Buffalo Bills and New Orleans Saints were embarrassed on the field last week. However, only the Saints find themselves limping to the gridiron for the Week 12 TNF showdown between these two teams.

Dropping to 6-4, the Bills, 41-15 losers to the Indianapolis Colts, relinquished top spot in the AFC East to the New England Patriots. At 5-5, the Saints, who lost their third straight contest via a 40-29 setback at Philadelphia, fell two games behind the division-leading Tampa Bay Buccaneers in the NFC South.

Injury-riddled New Orleans is a 6.5-point home underdog to the Bills in this game. Buffalo is 0-5 against the spread in the team’s last five visits to New Orleans. Kickoff for this game at Caesars Superdome is set for 8:20pm ET. FOX Sports is carrying the broadcast.

Bills vs Saints Betting Trends

Team Spread ATS Handle % ATS Bet % Total Over/Under Handle % Over/Under Bet % Moneyline ML Handle % ML Bet %
Buffalo Bills -6.5 84% 79% Over 45 54% 62% -275 83% 81%
New Orleans Saints +6.5 16% 21% Under 45 46% 38% +220 17% 19%

Trends as of November 25th at DraftKings.

Bills vs Saints Line Movement

Bettors are backing the Bills for a big bounce back win this week in a major manner in the NFL betting trends. Buffalo opened as 3.5-point favorites in this game. However, with 84% of handle and 79% of bets on the spread placed on the Bills, the line has lengthened to Bills -6.5.

NFL bettors are just as sold on the Bills in moneyline. There’s 80% of handle and 74% of bets supporting the Bills. That’s caused Buffalo’s moneyline to go from -198 to -275.

There’s 54% of handle and 62% of bets going with the over. The total has shortened on this game from 47 to 45 points.

Bills vs Saints Injury Report

Perhaps the best question to ask is which members of the Saints’ offense aren’t hurt? Quarterback Jameis Winston (knee) is on IR. Running backs Alvin Kamara (sprained MCL) and Mark Ingram (knee) are both questionable. Kamara missed the last two games.

According to Ian Rapoport of NFL.com, Kamara is out again Thursday and Ingram, who has swelling on the knee, is facing an uphill battle to be playing on Thursday. That would leave Tony Jones atop the New Orleans’ RB depth chart. In his second NFL season, Jones has played six games, carrying the ball 25 times for 92 yards.

Left guard Andrus Peat (pectoral) is on IR. Both starting tackles – Terron Armstead (kee) and Ryan Ramczyk (knee) – are questionable. Rookie Landon Young (foot), who made his first NFL start in place of Armstead last week, went on IR. Tight end Adam Trautman (knee), who caught a season-high five passes last week, also was placed on IR. All-Pro wide receiver Michael Thomas (ankle) is out. On defense, right defensive end Marcus Davenport (shoulder) is questionable.

For the Bills, right tackle Spencer Brown (COVID-19) and right defensive tackle Star Lotulelei (COVID-19) are questionable.

Bills vs Saints Team Trends

New Orleans is 8-1-1 ATS in its last 10 games as a home underdog. Saints QB Trevor Siemian is 0-3 as the starter since he took over for the injured Winston.

New Orleans was the NFL’s #1 run defense until the Eagles carved them up for 242 yards on the ground last week. Buffalo is #3 in the league at stopping the run, but also got lit up last week for 185 yards by NFL rushing leader Jonathan Taylor of Indianapolis.

Buffalo is 2-2 in its last four road games. The Saints are 3-2 in their last five home games.

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Robert Duff

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