Mariners vs Cardinals Picks & Predictions (Apr 25)

• The St Louis Cardinals look to even their series with the Seattle Mariners Saturday
• Seattle has reeled off five straight wins against the Cardinals
• Read below for the my Mariners vs Cardinals picks, predictions and latest odds

The St. Louis Cardinals (14-10) look to bounce back as home underdogs when they continue their series against the Seattle Mariners (11-15) on Saturday.

Seattle has reeled off five straight wins in this head-to-head, and, behind starter Bryan Woo, who has been dynamite the early going this season for the M’s they’ve earned the nod as road favorites in the MLB odds.

First pitch goes at 2:15pm ET from at Busch Stadium. in St Louis, with MLB TV providing the broadcast coverage.

Read below for my Mariners vs Cardinals picks and prediction, as well as the updated odds for this matchup.

Mariners vs Cardinals Odds

The graphic above shows the best available odds, which are subject to change

Despite being the road team with a poorer overall record, the Mariners enter this contest as definitive -145 moneyline favorites at Caesars, reflecting the immense respect oddsmakers have for Woo.

The runline opened with the road squad at -1.5 (+110) and the home squad at +1.5 (-130). Since then, the juice has shifted slightly, pushing the runline odds to +118 at BetMGM and making the home underdogs an even heavier -135 favorite to cover the spread at bet365.

Meanwhile, the game total opened has settled in at 7.5 runs with each side getting -105 juice at BetMGM and FanDuel.

Mariners vs Cardinals Picks & Predictions

• Best Bet: Mariners ML (-145 at BetMGM)

Because of a massive edge in reliable run prevention, I am backing the road team on the moneyline.

Neither of these offenses is lighting up the scoreboard right now, The Cardinals enter this matchup hitting just .237 at home with a middling .681 OPS. The Mariners have been even colder at the dish, batting a league-worst .173 on the road.

But the M’s have Bryan Woo on the mound Saturday, and he should have the advantage against lefty Matthew Liberatore.

Woo has been nothing short of dominant to start the 2026 campaign. Through 32.0 innings, he boasts a sterling 2.25 ERA and a microscopic 0.88 WHIP, limiting traffic on the basepaths and keeping opponents off balance. His success stems from elite command, walking just 1.69 batters per nine innings.

He’s also yet to surrender a home run this season. But he’s had to be that good for the Mariners to have a chance on the road, because the bats have been abysmal. Away from T-Mobile Park, they are mustering a meager 2.50 runs per game.

The good news is that as a team (and in a very small sample), the Mariners are hitting .333 against Liberatore, with an exceptional 1.036 OPS. Outfielder Randy Arozarena has done the most damage against him in five at-bats, with two hits, including one HR and four RBI.

While Liberatore’s 3.67 ERA over 27.0 innings is respectable, his 1.41 WHIP and 5.04 xFIP suggest he is dancing with danger far too often. He is currently allowing 9.33 hits per nine innings. Compounding the traffic on the bases is his lack of swing-and-miss stuff, as he relies heavily on his defense to get out of jams.

He is, however, coming off of one of his bets starts of the year, giving up just three hits and one earned run in six innings of work against the Astros, in a game St Louis eventually won 7-5 in extra innings.

Six of the last nine head-to-head meetings have resulted in a score difference of two or fewer runs, with the Mariners winning five of those close encounters to just a single victory for St Louis. I like the Mariners to eke out another close one Saturday.