Missouri vs Vanderbilt Spread, Best Bets & Score Prediction

• The 10th-ranked Vanderbilt Commodores are 3-point favorites vs the no. 15 Missouri Tigers in SEC action Saturday
• These teams rank inside the conference’s Top 3 in scoring
• See below for my Missouri vs Vanderbilt spread, best bets and score prediction

It’s one of the must-see matchups in Week 9 of the college football season, as the 15th-ranked Missouri Tigers (6-1, 2-1 SEC) visit the No. 10 Vanderbilt Commodores (6-1, 2-1 SEC).

Despite the Tigers having won five straight over Vandy, the college football odds have the home team as 3-point favorites. Soon, these spreads will be available at Missouri sports betting apps.

Kickoff is scheduled for Saturday at 3:30 pm ET from FirstBank Stadium in Nashville, TN, with ESPN carrying the broadcast.

Missouri vs Vanderbilt Spread & Line

This spread has fluctuated before settling in on Missouri as a 2.5-point underdog. The line shifted as far as one point in either direction into the lead-up of this week.

The moneyline has hardly been as interesting, with the Tigers checking in at +124, and Vanderbilt at -148.

The total can be found at 52.5 points, but you don’t have to look far to find this at a point higher if you plan to take the Under, or a point lower if you want to bet the Over.

Odds as of Oct. 25 at DraftKings. New customers can claim the DraftKings promo code and get a bonus to bet on college football. Missouri bettors should check out DraftKings Missouri ahead of the official launch.

Missouri vs Vanderbilt Best Bet

After dropping their first of the season in a loss to Alabama, Missouri got back into the win column with a tough, 23-17 2OT road win at Auburn.

One of the power running teams in all of college football, the Tigers ran for only 91 yards on 44 carries, but did punch it in three times to help move the 6-1 on the year and to 2-1 in the SEC.

While he did throw two interceptions, senior pivot Beau Pribula did throw for 252 yards, which was the most he’s had in any conference game this season. Pribula also added a rush TD.

Mizzou again leaned on its top-flight defense, which ranks fourth in the SEC in points allowed (16.7). Auburn is now the fifth team in seven games that Mizzou has held to 20 points or less this season.

Key Offensive Stats

That defense is going to have to find a way to contain Commodores’ pivot Diego Pavia, who might be the most dynamic player on the field for both teams.

The dual-threat star, a Top-4 contender in the current 2025 Heisman Trophy odds, was key in their 31-24 win over then-ranked 10th LSU. Pavia threw for 160 yards and a score, while leading the team in rushing with 86 yards and two majors. It’s the third time in four games he’s led the Commodores in rushing.

Vandy is in the middle of the meaty part of their schedule, as Missouri will be the third of four straight ranked teams they will face, all fighting for their place in the SEC.

Their offense is top eight in the nation, pouring in 41.4 points per game, but Missouri might have the defense to stop them. It can be done, as evidenced by Alabama holding Vandy to its lowest scoring output of the season in a 30-14 defeat.

In fact, that’s where I’m going with this wager: this matchup features two of the top three teams in scoring in the SEC, and two of the top 12 in college football.

However, once they got to conference play, the two teams have cashed the Under in five of six SEC head-to-heads. The only game to go over 53.5 points (the total set for Saturday) is the Vanderbilt-LSU.

And in this high-stakes battle, look for the offense to gear down vs go into shootout mode.

Missouri vs Vanderbilt Score Prediction

• Score Prediction: Vanderbilt 27-21

That doesn’t mean these sides won’t put up points: both are averaging an identical 25.3 points per game in SEC play.

I think Vanderbilt finally shakes this losing streak because they’ve got the best player on the field in Pavia, and they have been dynamite at home this year, going 4-0, scoring at least 31 points in each.