Predictions. Odds, Props & Picks

Oklahoma bounced back after losing to Texas by taking care of South Carolina. Oklahoma has a pair of ranked wins this season (Michigan and Auburn), but this week begins its stretch of five-straight ranked games to end the season. If Oklahoma goes 3-2 in this stretch, it could be enough to make the CFP, given the insane difficulty of the its schedule

Washington State transfer John Mateer was an early Heisman front-runner before getting hurt against Auburn. He rushed back from his hand injury, and it has shown. His last two games have not been sharp, but Mateer gives the Sooners the best chance to win.

With a compromised Mateer, Oklahoma has leaned on the rushing attack. An early-season committee has given way to a bellcow back: Tory Blaylock. Blaylock leads the team with 391 yards, and his four rushing touchdowns are second to Mateer. Xavier Robinson and Jaydn Ott have had varying degrees of success as change-of-pace backs.

Isaiah Sategna has led the line as the No.1 receiver, averaging 70.4 yards per game and scoring four touchdowns. Tight end Jaren Kanak is in the running for the Mackey Award, while Deion Burks has been a quality No.2 receiving option.

I’ll discuss the stud of the Oklahoma defense below, but the conference leader of the unit is Taylor Wein. He has an SEC-leading 10.5 tackles for loss. Wein also has 3.5 sacks and an interception to his name.

Ole Miss vs Oklahoma Pick

• Under 53.5 (-122, BetRivers)

Here are the primary reasons why I am taking Under 53.5 in this SEC showdown:

• Since returning from injury, John Mateer has not been his usual self. Oklahoma has averaged 16 points per game, and Mateer has one total touchdown with three interceptions. His passing, in particular, has been shaky. PFF credits him with zero big-time throws and eight turnover-worthy plays in his two games since coming back.
• Oklahoma has the nation’s No.2 scoring defense, allowing fewer than 10 points per game. Future top-50 pick R Mason Thomas is one of the best defenders in the country, recording 5.5 sacks and 7.5 tackles for loss. Oklahoma allows a 57.9% completion rate and 2.5. yards per rush. Both of these marks are top 25 nationally.
• Ole Miss has a couple of outburst offensive performances en route to a 37.4 points per game standing. However, their scoring in the last three games is just 27.7 points per game as the defenses the Rebels have faced have improved. Not only is Oklahoma one of the best defenses in the country, but Ole Miss is also in a bit of a cold spell, scoring 24 points against LSU and Washington State.

Ole Miss vs Oklahoma Betting Lines

The oddsmakers have Oklahoma as reasonable home favorites, with the total set between 51.5 and 53.5 points. Over bettors can get over 51.5 for -115 odds at ESPNBet. Under bettors can get under 53.5 at BetRivers for -122 odds.

Oklahoma bettors should take them -4.5 at Underdog (-115 odds) or -195 on the moneyline at ESPNBet. Ole Miss bettors should take them +5.5 at Fanatics (-110 odds) or +180 on the moneyline at DraftKings.

Odds as of October 24, 2025, at our top recommended College Football Betting Apps.

Ole Miss vs Oklahoma Props

• John Mateer (OU) Under 243.5 Passing Yards (-139, Sleeper)

Mateer has averaged just 176 passing yards per game since returning from injury. While he cleared this prop in all four healthy games, I have my doubts he will be healthy enough as a thrower to get into the mid-200s for a passing total.

Mateer should be a bigger influence on the ground, and he will have some key throws, but I do not believe the volume will be there for Mateer to hit his over on Saturday.

• Tory Blaylock (OU) Over 55.5 Rushing Yards (-114, FanDuel)

Blaylock has finally established himself as the lead back in the Oklahoma backfield. For the season, he has cleared 55.5 yards three times, rushing for a season-high 101 yards last week.

Blaylock could be an option for a betting ladder as he could go well over the 55.5 line.

Ole Miss has allowed seven 60+ rushers, four 70+ rushers, three 80+ rushers, two 90+ rushers, and one 100-yard rusher. Blaylock has two games with 100 rushing yards and a game with 78 rushing yards.

• Trinidad Chambliss (MISS) Under 35.5 Rushing Yards (-115, BetMGM)

Given Chambliss’ exceptional rushing ability, this is quite a low line, but I am backing Oklahoma to sack Chambliss multiple times and accrue negative rushing yards to offset some of the big plays Chambliss has on the day. Chambliss has gone under 35.5 rushing yards just three times, but he has only 57 yards on his last 20 carries.

Chambliss could go screaming over this total; his season-best is 112 yards, but the NCAA’s sack yardage rule leans in my favor here.

Ole Miss vs Oklahoma, Lifetime Matchups

Ole Miss and Oklahoma have only squared off in their programs’ histories. They first played in the 1999 Independence Bowl, with Ole Miss winning on a last-second field goal. They played for the first time as SEC opponents last season, with Ole Miss overcoming a halftime deficit to win.

In last season’s contest, future Auburn transfer Jackson Arnold threw a pair of touchdowns for the Sooners. On the Ole Miss side, future first-round pick Jaxson Dart threw for 311 yards and a touchdown. Suntarine Perkins had a whopping 4.0 sacks and 5.0 tackles for a loss, accounting for four of Ole Miss’s nine sacks on the day.