Predictions & Props to Bet in Yankees vs Red Sox on April 23

• The New Yankees are road favorites behind starter Cam Schlittler as they battle the Boston Red Sox
• The Boston Red Sox have struggled due to injuries, so it will be interesting to see how the Yankees approach today’s game
• Keep reading to see my best player prop bets, predictions, and the latest odds for this American League contest

The New York Yankees (15-9) and Boston Red Sox (9-15) continue their series tonight at Fenway Park. New York enters as the confident road favorite after securing a 4-1 victory in yesterday’s matchup. In that contest, Max Fried delivered a strong start, backed by a clutch home run from Amed Rosario. The underdog Red Sox struggled to generate run support, managing just one late run against a stout bullpen.

As these longtime rivals prepare for their next clash—scheduled for 6:10 PM ET on April 23, 2026—I am looking for the best angles on the board. The Yankees hand the ball to probable starter Cam Schlittler, while Boston counters with Payton Tolle in hopes of finding an offensive spark. Read on as I break down the positional advantages, evaluate both rosters, and provide my top betting predictions for tonight’s American League showdown.

Yankees vs Red Sox Odds

Odds as of April 23, 2026, at 11:05 AM ET from BetMGM, Caesars, and DraftKings

Given the pitching mismatch and New York’s strong start to the season, bettors must lay juice to back the road favorites to win outright. Removing the vig from the moneyline, the Yankees have an implied win probability of 60.78% compared to Boston’s 43.48%. For runline bettors, backing New York to win by multiple runs yields a favorable +109 payout.

Looking at the opening MLB odds, there has been fascinating line movement. The total originally opened at 8.5 but was bet down to a flat 8. The runline experienced reverse line movement, opening with New York at -1.5 (+104) before lengthening to (+109), indicating sportsbooks took respected early action on Boston, keeping it competitive.

Injury Report & Betting Impact

Boston’s rotation is absolutely decimated. With five key starters sidelined, the Red Sox are operating with a makeshift staff, directly explaining their bloated 4.39 team ERA. Offensively, missing Triston Casas and Roman Anthony leaves a lineup that already ranks 29th in home run production at home incredibly vulnerable. Meanwhile, New York has brilliantly masked the absences of Gerrit Cole and Carlos Rodón, maintaining an MLB-best 3.16 ERA through elite organizational pitching depth.

Pitching Matchup & Team Stats

Note: Early-season data for Tolle is unavailable as he makes his first major impact of 2026.

Schlittler has been unhittable through 27.2 innings. Boasting an elite 1.86 xFIP and issuing just 0.98 walks per nine innings, his surface-level dominance is rooted in elite command. On the other side, Tolle is a complete wild card. Facing a prolific offense without an established regular-season track record puts the southpaw in a high-pressure spot. Because Tolle lacks data and Schlittler is fresh into his breakout run, no head-to-head batter vs pitcher (BvP) data exists for either lineup tonight, traditionally giving the early advantage to the arms.

New York’s sheer gap in power and hard-hit rate makes backing their star players an enticing angle. The team leads all MLB road squads with a 90.0 mph average exit velocity. Slugging right fielder Aaron Judge is primed to exploit this leaky pitching staff, while breakout first baseman Ben Rice continues to be an offensive catalyst.

Betting Splits & Trends

Tracking how the MLB public betting percentages and sharp money attack the board provides vital context. There are currently no “sharp vs public” splits to exploit, as the ticket count and financial handle are firmly aligned across all major markets.

• Moneyline Splits: 90% of the money and 82% of tickets are backing New York.
• Runline Splits: 83% of the money is laying the runs with New York -1.5.
• Total Splits: 65% of the money sits on the Over, though late ticket volume shows a slight uptick toward the Under.

When evaluating the situational betting angles, several concrete trends support New York:

• Yankees Recent Form: New York boasts a 70.0% win rate over their last 10 games (7-3).
• Yankees as Favorites: New York has won 66.7% of their games when favored over their last 10 matchups (6-3).
• Yankees Totals: The Under has hit in 60.0% of New York’s last 10 contests.
• Red Sox as Underdogs: Boston is completely winless when playing as an underdog this year, posting an 0-4 (.000) record.

Predictions & Best Bets

Trusting the season-long metrics provides the clearest path to value tonight. While I do not base my picks solely on public betting splits, the overwhelming financial stake on New York aligns perfectly with the statistical mismatches I have uncovered.

Moneyline Pick: New York Yankees (-155 via Caesars)
Given the pitching mismatch and superior run production, backing the road favorite is my most logical moneyline angle. Boston simply lacks the offensive firepower to keep pace if their depleted rotation continues to struggle.

Over/Under Pick: Under 8 (-118 via BetMGM)
With Schlittler’s ability to shut down lineups and Boston hitting just .217 at home, scoring opportunities will be heavily restricted. Coupled with a respectable Boston bullpen, I expect a methodical, pitching-centric script that stays under the projected total.

Best Player Prop: Cam Schlittler Over 6.5 Pitcher Strikeouts (+115 at bet365)
Schlittler is averaging 11.71 strikeouts per nine innings. Given his ability to pitch deep into games and Boston’s tendency to swing and miss, getting plus money for seven punchouts offers tremendous value.

Odds as of April 23, 2026, at 11:05 AM ET from BetMGM, bet365, and Caesars