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- #3 Michigan State meets #6 Louisville in the round of 32
- Tom Izzo’s Spartans are slight chalk
- See the opening Michigan State vs Louisville odds for the second round
The #3 Michigan State Spartans (26-7, 16-15-2 ATS) made quick work of #14 North Dakota State on Thursday, setting up a heavyweight second-round tilt with the #6 Louisville Cardinals (24-10, 17-17 ATS) on Saturday, March 21st (start time TBD).
Louisville held off a spirited comeback attempt from #11 USF (83-79) but the opening Louisville vs Michigan State odds project the Cardinals’ tournament ending this weekend.
Michigan State vs Louisville Opening Odds
MSU is a 3.5-point favorite against the spread and -185 on the moneyline. The Cardinals come back as +154 underdogs. The game total has opened at 150.5 with -110 odds both ways.
Odds os of 6:45 pm ET at DraftKings. See the full list of sports betting apps for March Madness.
Virginia transfer Isaac McKneely led the way for Louisville on Thursday, scoring 23 points on an electric 7-of-10 performance from beyond the arc.
Louisville vs Michigan State 2025 Team Stats
MSU and Louisville haven’t played since January 2021, when the Spartans took a 73-64 win in East Lansing.
Check SBD’s college basketball public betting splits to see where the money is going on this game and all 67 NCAA Tournament matchups.