Predictions & Best Bets for Dodgers vs Astros

• The Dodgers are -215 moneyline favorites versus the Astros this afternoon
• LA and Houston have split the first two games of this series
• See my favorite predictions and best bets for Dodgers vs Astros below

The Houston Astros host the Los Angeles Dodgers at Daikin Park this afternoon with first pitch set for 2:10 PM ET. LA is positioned as heavy road favorites in the MLB odds, looking to bounce back from last night’s narrow 2-1 loss. The Astros meanwhile, are aiming to prove their recent run prevention is no fluke, and claim a second consecutive victory as a home underdog.

Keep reading for my favorite predictions and best bets for the Dodgers vs Astros series finale below.

Predictions for Dodgers vs Astros

• Dodgers Moneyline (-215 at Bet365)
• Over 8.5 Runs (-120 at BetMGM)

My two favorite predictions for today’s Dodgers vs Astros matchup are the LA moneyline and over 8.5 runs. The starting pitching disparity makes the Dodgers a clear choice on the moneyline.

The Dodgers have been a reliable straight-up bet this season, winning 61.1% of their games (22-14 overall). In contrast, the Astros have struggled to notch victories so far, posting a 15-22 record. Furthermore, the Astros have hit the Under at just a 27.0% clip this season, establishing a 73.0% trend toward the Over. These statistical angles shape my primary picks for today’s slate.

Tyler Glasnow vs Lance McCullers Jr Stats

Let’s dig into the MLB starting pitchers and lineups . LA’s Tyler Glasnow has been a highly effective starter this season. Opponents manage a .146 batting average against him. His 3.06 FIP lines up well with his 2.56 ERA, indicating that his run prevention is fully supported by underlying metrics. He averages 6.44 innings per start over his last 10 appearances, providing reliable length.

Houston will counter with Lance McCullers Jr, who enters this matchup carrying a 6.32 ERA and struggles with command, issuing 4.9 walks per nine innings. This lack of control limits his efficiency, forcing the Astros to dip into their bullpen after an average of only 5.2 innings. While his 4.51 FIP suggests some poor luck relative to his ERA, issuing free passes is a difficult strategy to sustain against a deep lineup.

Dodgers vs Astros Stats

The statistics highlight why the Dodgers are heavily favored. The Dodgers plate 5.61 runs per game on the road, backed by a .287 batting average and an .815 OPS. The Astros bat just .236 at home, relying primarily on isolated power. Neither team is particularly aggressive on the basepaths, meaning station-to-station slugging will dictate run production. The most pronounced mismatch comes defensively. The Dodgers lead Major League Baseball in run prevention, surrendering just 3.25 runs per game. The Astros allow 5.68 runs per contest, ranking 29th overall.

Best Bets for Dodgers vs Astros

• Tyler Glasnow Over 7.5 Strikeouts (+114 at DraftKings)

Switching gears to the MLB props mraket, where I’m betting Over 7.5 Strikeouts for Glasnow. The righty strikes out 10.94 batters per 9 innings, and will face an Astros lineup that has struck out 332 times this year. Glasnow doesn’t have a ton of experience versus this version of the Houston lineup, but the Astros bats that have faced him have not fared well.

Per the MLB batter vs pitcher stats, Glasnow has held Houston hitters to a .176 batting average over 34 at-bats, with a 35.2% strikeout rate.

Odds for Dodgers vs Astros

Odds as of May 6. Claim the BetMGM promo code to bet on MLB today.

Betting Splits for Dodgers vs Astros

Moving over to the MLB public betting splits, where the moneyline market sees lopsided action backing the road favorites. A decisive 90.0% of all moneyline tickets are on the Dodgers.

The action on the total runs market leans toward the Over, drawing 79.9% of the betting tickets and 65.7% of the total stake. Both the ticket count and the money firmly back a higher-scoring affair, aligning with expectations of offensive production against a struggling starter.